CLINICAL RESEARCH

The Gamma Knife of Spokane Clinical Research Program is a collaborative research approach between surgeons, radiation oncologists, neuro-otologists, and medical physicists. This group places research emphasis on investigating the clinical outcomes of patients who undergo Gamma Knife Radiosurgery as a treatment for benign and malignant conditions of the brain and head and neck regions. We feel that progress in radiosurgical techniques requires a unique blend of clinical specialties to fully understand treatment challenges and options for improving patient outcomes.

The Gamma Knife of Spokane has been identified by the manufacturer (Elekta) as the "best example of a community-based Gamma Knife facility in the United States."  

This collaborative group of surgeons, radiation oncologists, neurotologist and clinical support staff has access to shared hospital resources, as well as our mature clinical database of over 3,000 patients since 2002.

The result of this collaboration and data has yielded 22 peer-reviewed clinical study publications and 4 invited book chapters. 

METASTATIC TUMORS


Long-term survival in a patient with multiple brain metastases from small-cell lung cancer treated with Gamma Knife radiosurgery on four occasions: a case report.

Elaimy AL, Thumma SR, Lamm AF, Mackay AR, Lamoreaux WT, Fairbanks RK, Demakas JJ, Cooke BS, Lee CM. Case Rep Neurol Med. 2012;2012:276189. doi: 10.1155/2012/276189. Epub 2012 Oct 4.

Long-Term Survival of a Patient with Brainstem and Recurrent Brain Metastasis from Stage IV Nonsmall Cell Lung Cancer Treated with Multiple Gamma Knife Radiosurgeries and Craniotomies: A Case Report and Review of the Literature.

Lamm AF, Elaimy AL, Mackay AR, Fairbanks RK, Demakas JJ, Cooke BS, Lee CM, Taylor BS, Lamoreaux WT. Case Rep Oncol Med. 2012;2012:621641. doi: 10.1155/2012/621641. Epub 2012 Sep 29.

A concise review of the efficacy of stereotactic radiosurgery in the management of melanoma and renal cell carcinoma brain metastases.

Hanson PW, Elaimy AL, Lamoreaux WT, Demakas JJ, Fairbanks RK, Mackay AR, Taylor B, Cooke BS, Thumma SR, Lee CM. World J Surg Oncol. 2012 Aug 29;10:176. doi: 10.1186/1477-7819-10-176.

 

Multimodality treatment of brain metastases: an institutional survival analysis of 275 patients.

Elaimy AL, Mackay AR, Lamoreaux WT, Fairbanks RK, Demakas JJ, Cooke BS, Peressini BJ, Holbrook JT, Lee CM. World J Surg Oncol. 2011 Jul 5;9(1):69.

Clinical outcomes of stereotactic radiosurgery in the treatment of patients with metastatic brain tumors.

Elaimy AL, Mackay AR, Lamoreaux WT, Fairbanks RK, Demakas JJ, Cooke BS, Lee CM. World Neurosurg. 2011 May-Jun;75(5-6):673-83.

Brain metastases: clinical outcomes for stereotactic radiosurgery (method).

Elaimy AL, Mackay AR, Lamoreaux WT, Fairbanks RK, Demakas JJ, Cooke BS, Arthurs BJ, Lee CM. Tumors of the Central Nervous System. Ed. M.A. Hayat. Vol. 3. Springer: New York, 2011.


PRIMARY BRAIN TUMORS


Effect of pretreatment clinical factors on overall survival in glioblastoma multiforme: a Surveillance Epidemiology and End Results (SEER) population analysis.

Thumma SR, Fairbanks RK, Lamoreaux WT, Mackay AR, Demakas JJ, Cooke BS, Elaimy AL, Hanson PW, Lee CM. World J Surg Oncol. 2012 May 3;10:75. doi: 10.1186/1477-7819-10-75.

Long-term survival after Gamma Knife radiosurgery in a case of recurrent glioblastoma multiforme: a case report and review of the literature.

Thumma SR, Elaimy AL, Daines N, Mackay AR, Lamoreaux WT, Fairbanks RK, Demakas JJ, Cooke BS, Lee CM. Case Rep Med. 2012;2012:545492. doi: 10.1155/2012/545492. Epub 2012 Apr 4.

Olfactory neuroblastoma treated by endoscopic surgery followed by combined external beam radiation and gamma knife for optic nerve and chiasm sparing: a case report.

Jiang HZ, Elaimy AL, Jones GC, Mackay AR, Fairbanks RK, Lamoreaux WT, Demakas JJ, Cooke BS, Lee CM. Case Report Med. 2011;2011:765645. doi: 10.1155/2011/765645. Epub 2011 Nov 9.

 

Olfactory neuroblastoma treated by endoscopic surgery followed by combined external beam radiation and gamma knife for optic nerve and chiasm sparing: a case report.

Jiang HZ, Elaimy AL, Jones GC, Mackay AR, Fairbanks RK, Lamoreaux WT, Demakas JJ, Cooke BS, Lee CM. In press.

Long term survival after Gamma Knife radiosurgery in a case of recurrent glioblastoma multiforme: a case report and review of the literature.

Thumma SR, Mackay AR, Lamoreaux WT, Fairbanks RK, Demakas JJ, Cooke BS, Elaimy AL, Lee CM. In press. Invited Textbook Chapters

 

ACOUSTIC NEUROMAS


A review of treatment modalities for vestibular schwannoma.

Arthurs BJ, Fairbanks RK, Demakas JJ, Lamoreaux WT, Giddings NA, Mackay AR, Cooke BS, Elaimy AL, Lee CM. Neurosurg Rev. 2011 Jul;34(3):265-79.

Gamma Knife radiosurgery for vestibular schwannomas: tumor control and functional preservation in 70 patients.

Arthurs BJ, Lamoreaux WT, Mackay AR, Demakas JJ, Giddings NA, Fairbanks RK, Cooke BS, Elaimy AL, Peressini B, Lee CM. Am J Clin Oncol. 2011 Jun;34(3):265-9.

Gamma knife radiosurgery for vestibular schwannoma: case report and review of the literature.

Arthurs BJ, Lamoreaux WT, Giddings NA, Fairbanks RK, Mackay AR, Demakas JJ, Cooke BS, Lee CM. World J Surg Oncol. 2009 Dec 18;7:100.

 

Vestibular schwannoma: Gamma Knife radiosurgery (method).

Arthurs BJ, Fairbanks RK, Demakas JJ, Lamoreaux WT, Giddings NA, Mackay AR, Cooke BS, Elaimy AL, Lee CM. Tumors of the Central Nervous System. Ed. M.A. Hayat. Springer: New York, 2011. In press.

 

TRIGEMINAL NEURALGIA


Clinical outcomes of gamma knife radiosurgery in the treatment of patients with trigeminal neuralgia.

Elaimy AL, Hanson PW, Lamoreaux WT, Mackay AR, Demakas JJ, Fairbanks RK, Cooke BS, Thumma SR, Lee CM. Int J Otolaryngol. 2012;2012:919186. doi: 10.1155/2012/919186. Epub 2011 Oct 25.

Feasibility of multiple repeat gamma knife radiosurgeries for trigeminal neuralgia: a case report and review of the literature.

Jones GC, Elaimy AL, Demakas JJ, Jiang H, Lamoreaux WT, Fairbanks RK, Mackay AR, Cooke BS, Lee CM. Case Report Med. 2011;2011:258910. doi: 10.1155/2011/258910. Epub 2011 Sep 4.

Clinical outcomes of gamma knife radiosurgery in the treatment of patients with trigeminal neuralgia.

Elaimy AL, Lamoreaux WT, Mackay AR, Demakas JJ, Fairbanks RK, Cooke BS, Thumma SR, Lee CM. Int J Otolaryngol. In press.

 

Feasibility of multiple repeat gamma knife radiosurgeries for trigeminal neuralgia: a case report and review of the literature.

Jones GC, Elaimy AL, Demakas JJ, Jiang H, Lamoreaux WT, Fairbanks RK, Mackay AR, Cooke BS, Lee CM. Case Report Med. In press.

Atypical tongue pain from trigeminal neuralgia: gamma knife as a treatment strategy.

Elaimy AL, Lamoreaux WT, Mackay AR, Fairbanks RK, Demakas JJ, Cooke BS, Hanson PW, Lee CM. Tongue: Anatomy, Kinematics and Diseases. Nova: New York. In press.

 

ESSENTIAL TREMORS


Gamma knife radiosurgery for movement disorders: a concise review of the literature.

Elaimy AL, Arthurs BJ, Lamoreaux WT, Demakas JJ, Mackay AR, Fairbanks RK, Greeley DR, Cooke BS, Lee CM. World J Surg Oncol. 2010 Jul 21;8:61.

Gamma Knife radiosurgery for essential tremor: a case report and review of the literature.

Elaimy AL, Demakas JJ, Arthurs BJ, Cooke BS, Fairbanks RK, Lamoreaux WT, Mackay AR, Greeley DR, Lee CM. World J Surg Oncol. 2010 Mar 22;8:20.

Gamma Knife thalamotomy for disabling tremor: an alternative to deep brain stimulation.

Elaimy AL, Demakas JJ, Mackay AR, Lamoreaux WT, Fairbanks RK, Cooke BS, Lee CM. Deep Brain Stimulation: New Developments, Procedures and Applications. Nova: New York. In press.